The reduction in the numbers of new molecules coming to market, along with the expiry of certain patents is forcing a fundamental shift in how medicines are developed and manufactured. In addition, healthcare systems around the world are demanding access to cost-effective and innovative medicines with improved patient compliance. These present unique manufacturing challenges that need to be tackled effectively for scale-up and delivering to large numbers of any population. Also, approximately 40% of all drugs suffer with solubility problems making them less effective and sometimes non viable, contributing to the sharp rise in costs and timescales fro drug development. Thus, there is a clear need to develop methods to make drugs more soluble and usable, combined with manufacturing processes and techniqiues that are suitable for scale-up. Our unique technology and techniques overcome most of the associated challenges with poorly water-soluble drugs processing and manufacturing.